Isaiah 8:14 describes the Lord as a stone of stumbling and a rock of offense, which Peter references in 1 Peter 2:8 to describe Jesus as the cornerstone rejected by those who do not believe.
Thematic focusRejection of the Messiah, Stumbling Stone.
Isaiah 8:18 refers to the children given as signs and wonders in Israel, which is quoted in Hebrews 2:13 to illustrate the role of Jesus and His followers as signs to the people.
Thematic focusSigns and Wonders, Messianic Fulfillment.
Isaiah 8:22 describes a time of distress and darkness, which is contrasted with the light brought by Jesus in Matthew 4:16, fulfilling the prophecy of light coming to those in darkness.
Thematic focusLight in Darkness, Fulfillment in Christ.