Genesis 48:5 records Jacob adopting Ephraim and Manasseh as his own sons, which is later reflected in 1 Chronicles 5:1-2, where the birthright is given to Joseph's sons, emphasizing their importance in Israel's tribal structure.
Genesis 48:14 describes Jacob crossing his hands to bless Ephraim over Manasseh, which is highlighted in Hebrews 11:21 as an act of faith, showing Jacob's trust in God's promises and plans.
In Genesis 48:16, Jacob speaks of the Angel who redeemed him from all evil, echoing God's promise in Genesis 28:15 to be with Jacob and keep him wherever he goes, highlighting God's faithfulness and protection.
Genesis 48:19 predicts that Ephraim will become greater than Manasseh, which is confirmed in Numbers 1:32-33, where Ephraim's descendants are more numerous, fulfilling Jacob's prophetic blessing.
Genesis 48:20 records Jacob blessing Ephraim and Manasseh, saying they will be a model for blessings in Israel, which is echoed in Deuteronomy 33:17, where Joseph's descendants are described as powerful and numerous.